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Antimutagenic activity of afobazole in various regimens of treatment.

Authors
  • Zhanataev, A K
  • Durnev, A D
  • Seredin, S B
Type
Published Article
Journal
Bulletin of experimental biology and medicine
Publication Date
Nov 01, 2000
Volume
130
Issue
11
Pages
1077–1079
Identifiers
PMID: 11182820
Source
Medline
License
Unknown

Abstract

The influence of a new 2-mercaptobenzimidazole derivative afobazole on cytogenetic effects of dioxidine and cyclophosphamide was studied by counting chromosome aberrations in bone marrow cells of C57Bl/6 mice. Afobazole (1-100 mg/kg perorally) exhibited antimutagenic activity determined by its antioxidant properties. This activity depended on the dose and treatment schedule.

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