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Antimicrobial resistance profiles of Campylobacter jejuni and Salmonella spp. isolated from enteritis patients in Japan.

Authors
  • Sasaki, Yoshimasa1, 2, 3
  • Ikeda, Tetsuya4
  • Yonemitsu, Kenzo5
  • Kuroda, Makoto6
  • Ogawa, Miho7
  • Sakata, Ryuji7
  • Uema, Masashi1
  • Momose, Yoshika1
  • Ohya, Kenji8
  • Watanabe, Maiko8
  • Hara-Kudo, Yukiko8
  • Okamura, Masashi3
  • Asai, Tetsuo2
  • 1 Division of Biomedical Food Research, National Institute of Health Sciences.
  • 2 Department of Applied Veterinary Science, The United Graduate School of Veterinary Science, Gifu University.
  • 3 Division of Veterinary Science, Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine.
  • 4 Department of Infectious Diseases, Hokkaido Institute of Public Health.
  • 5 Murayama Branch, National Institute of Infectious Diseases.
  • 6 Pathogen Genomics Center, National Institute of Infectious Diseases.
  • 7 Department of Bacteriology, BML Inc.
  • 8 Division of Microbiology, National Institute of Health Sciences.
Type
Published Article
Journal
The Journal of veterinary medical science
Publication Date
Mar 03, 2023
Identifiers
DOI: 10.1292/jvms.22-0424
PMID: 36878553
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Understanding the antimicrobial resistance of Campylobacter jejuni and Salmonella spp. isolated from patients with enteritis will aid in therapeutic decision-making. This study aimed to characterize C. jejuni and Salmonella spp. isolates from patients with enteritis. For C. jejuni, the resistance rates against ampicillin, tetracycline, and ciprofloxacin were 17.2%, 23.8%, and 46.4%, respectively. All the C. jejuni isolates were susceptible to erythromycin, which is recommended as a first-choice antimicrobial if Campylobacter enteritis is strongly suspected. C. jejuni was classified into 64 sequence types (STs), and the five major STs were ST22, ST354, ST21, ST918, and ST50. The ciprofloxacin-resistance rate of ST22 was 85.7%. For Salmonella, the resistance rates against ampicillin, cefotaxime, streptomycin, kanamycin, tetracycline, and nalidixic acid were 14.7%, 2.0%, 57.8%, 10.8%, 16.7%, and 11.8%, respectively. All the Salmonella spp. isolates were susceptible to ciprofloxacin. Therefore, fluoroquinolones are the recommended antimicrobials against Salmonella enteritis. S. Thompson, S. Enteritidis, and S. Schwarzengrund were the three most prevalent serotypes. The two cefotaxime-resistant isolates were serotyped as S. Typhimurium and were found to harbor blaCMY-2. The results of this study would help select antimicrobials for treating patients with Campylobacter and Salmonella enteritis.

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