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Antimicrobial polypeptides are key anti-HIV-1 effector molecules of cervicovaginal host defense.

Authors
  • Cole, Alexander M
  • Cole, Amy Liese
Type
Published Article
Journal
American journal of reproductive immunology (New York, N.Y. : 1989)
Publication Date
Jan 01, 2008
Volume
59
Issue
1
Pages
27–34
Identifiers
PMID: 18154593
Source
Medline
License
Unknown

Abstract

Mucosal surfaces of the cervix and vagina are portals for heterosexual transmission of human immunodeficiency virus type 1 (HIV-1) and, therefore, play a fundamental role in the pathogenesis of primary infection. Cationic antimicrobial polypeptides including defensins are the principal effector molecules of mucosal innate immunity against microbes and viruses such as HIV. In cervicovaginal secretions, antimicrobial polypeptides constitute the majority of the intrinsic anti-HIV-1 activity, synergism between cationic polypeptides is complex, and full anti-HIV-1 activity involves the complete complement of cationic polypeptides. Periods in which cationic antimicrobial polypeptide expression is reduced are likely associated with increased susceptibility to HIV-1 infection. This review provides an overview of the role of cationic antimicrobial polypeptides in innate cervicovaginal anti-HIV-1 host defense, and discusses how hormones and bacterial infections can regulate their expression. Emphasis is placed on the theta-defensin (retrocyclin) class of anti-HIV-1 peptides and their potential for development as topical microbicides to prevent HIV-1 transmission.

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