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Antimicrobial activity of three tick defensins and four mammalian cathelicidin-derived synthetic peptides against Lyme disease spirochetes and bacteria isolated from the midgut

Authors
  • Isogai, Emiko1
  • Isogai, Hiroshi2
  • Takahashi, Koichi2
  • Kobayashi-Sakamoto, Michiko1
  • Okumura, Kazuhiko3
  • 1 Health Sciences University of Hokkaido, Department of Disease Control and Molecular Epidemiology, Ishikari-Tobetsu 1757, Hokkaido, 061-0293, Japan , Hokkaido (Japan)
  • 2 Sapporo Medical University, Animal Research Center, Minami 1 Nishi 16, Sapporo, 060-8556, Japan , Sapporo (Japan)
  • 3 Health Sciences University of Hokkaido, Department of Oral Surgery, Ishikari-Tobetsu 1757, Hokkaido, 061-0293, Japan , Hokkaido (Japan)
Type
Published Article
Journal
Experimental and Applied Acarology
Publisher
Springer-Verlag
Publication Date
Feb 20, 2009
Volume
49
Issue
3
Pages
221–228
Identifiers
DOI: 10.1007/s10493-009-9251-5
Source
Springer Nature
Keywords
License
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Abstract

In this study, chemically synthesized tick defensins and cathelicidin-derived mammalian peptides were used to investigate the activity spectrum against Borrelia garinii and symbiotic Stenotrophomonas maltophila. Synthetic tick defensins showed antimicrobial activity against Staphylococcus aureus but not B. garinii and S. maltophila. Mammalian peptides which have cationic property similar to tick defensins, showed antimicrobial activity similar to tick defensins. The antimicrobial peptides in ticks and mammalian hosts have common characteristics against microbial invasion in the innate immune system.

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