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Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts.

Authors
  • Crowston, J G
  • Akbar, A N
  • Constable, P H
  • Occleston, N L
  • Daniels, J T
  • Khaw, P T
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Feb 01, 1998
Volume
39
Issue
2
Pages
449–454
Identifiers
PMID: 9478007
Source
Medline
License
Unknown

Abstract

Mitomycin-C and high-dose 5-fluorouracil induce apoptosis in cultured Tenon's fibroblasts. Mitomycin-C-induced apoptosis is inhibited by fetal calf serum, indicating that exogenous factors influence the susceptibility of a fibroblast population to apoptosis. The induction and regulation of fibroblast apoptosis provides a novel target for the potential regulation of scarring.

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