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Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts.

Authors
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
0146-0404
Publisher
Association for Research in Vision and Opthalmology
Publication Date
Volume
39
Issue
2
Pages
449–454
Identifiers
PMID: 9478007
Source
Medline

Abstract

Mitomycin-C and high-dose 5-fluorouracil induce apoptosis in cultured Tenon's fibroblasts. Mitomycin-C-induced apoptosis is inhibited by fetal calf serum, indicating that exogenous factors influence the susceptibility of a fibroblast population to apoptosis. The induction and regulation of fibroblast apoptosis provides a novel target for the potential regulation of scarring.

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