Affordable Access

deepdyve-link
Publisher Website

Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds.

Authors
  • Duarte, Noélia
  • Kayser, Oliver
  • Abreu, Pedro
  • Ferreira, Maria-José U
Type
Published Article
Journal
Phytotherapy Research
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 01, 2008
Volume
22
Issue
4
Pages
455–457
Identifiers
DOI: 10.1002/ptr.2334
PMID: 18167046
Source
Medline
License
Unknown

Abstract

In the search for biologically active compounds from Euphorbia lagascae Spreng, an herbaceous plant native to southeast of Iberic Peninsula, a stilbene, two coumarins and two 12-deoxyphorbol diterpene esters were isolated by chromatographic methods, from the methanol extracts of its defatted seeds. The structures of these compounds were elucidated by a combination of physical and spectral data (IR, MS and high-resolution (1)H-NMR and (13)C-NMR spectroscopy utilizing COSY, HMBC, HMQC and NOESY experiments). The stilbene, piceatannol, was screened for its antileishmanial activity against promastigotes as an extracellular form of Leishmania donovani, Leishmania infantum and Leishmania major, and amastigotes of Leishmania donovani as an intracellular form. Pentostan (sodium stibogluconate), the first line clinical drug, was used as a standard reference. Piceatannol was moderately active against the extracellular forms of the three tested Leishmania species, and more active than the reference compound against the intracellular form of Leishmania donovani.

Report this publication

Statistics

Seen <100 times