Affordable Access

deepdyve-link
Publisher Website

Anti-inflammatory and ulcerogenic activity of newer phytoisolates of Swertia alata C.B. Clarke.

Authors
  • Bajaj, Sakshi1
  • Wakode, Sharad2
  • Kaur, Avneet2
  • Fuloria, Shivkanya3
  • Fuloria, Neeraj3
  • 1 Department of Pharmacognosy and Phytochemistry, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, New Delhi, India. , (India)
  • 2 Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, New Delhi, India. , (India)
  • 3 Pharmaceutical Chemistry Unit, Faculty of Pharmacy, AIMST University, Kedah Darul Aman, Malaysia. , (Malaysia)
Type
Published Article
Journal
Natural product research
Publication Date
Jun 05, 2020
Pages
1–11
Identifiers
DOI: 10.1080/14786419.2020.1775224
PMID: 32498574
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The present study was intended to evaluate the in vitro (COX-1/COX-2) and in vivo anti-inflammatory and ulcerogenic activity of newer phytoconstituents isolated from the aerial parts of Swertia alata C.B. Clarke (Gentianaceae). For isolation of newer phytoconstituents, the ethanolic extract of aerial parts of S. alata was subjected to column chromatography using mixture of petroleum ether and chloroform in various concentrations, which yielded two phytoisolates characterised as nonacosyl triacontanoate (SA-3) and 8-O-glucpyranosyl-(2-acetyl)-1,3-dihydroxy-5-methoxy-xanthone (SA-9). Identification of compounds was based on melting point, UV, FTIR, 1H-NMR, 13C-NMR and mass spectrometric data. The isolates were screened for in vitro COX-1/COX-2 inhibitory activity, in vivo anti-inflammatory and ulcerogenic activity. Among the two compounds, SA-3 was found to be more effective than SA-9. The ulcerogenic study revealed significant gastric tolerance of SA-3 and SA-9 in comparison to indomethacin.

Report this publication

Statistics

Seen <100 times