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Anti-Hepatitis B Virus Activity of New 1,2,4-Triazol-2-yl- and 1,3,4-Oxadiazol-2-yl-2-pyridinone Derivatives

Authors
  • El-Essawy, Farag A.
  • El-Sayed, Wael A.
  • El-Kafrawy, Sherif A.
  • Morshedy, Asmaa S.
  • Abdel-Rahman, Adel-H.
Type
Published Article
Journal
Zeitschrift für Naturforschung C
Publisher
Walter de Gruyter GmbH
Publication Date
Oct 01, 2008
Volume
63
Issue
9-10
Pages
667–674
Identifiers
DOI: 10.1515/znc-2008-9-1010
Source
De Gruyter
Keywords
License
Green

Abstract

A number of 1,3,4-oxadiazole, 3 - 9, and 1,2,4-triazole derivatives, 13 - 15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a - c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a - e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some of these compounds showed high antiviral activity

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