Affordable Access

Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.

Authors
  • Giacomini, P
  • Mottolese, M
  • Fraioli, R
  • Benevolo, M
  • Venturo, I
  • Natali, P G
Type
Published Article
Journal
British journal of cancer
Publication Date
Aug 01, 1992
Volume
66
Issue
2
Pages
342–344
Identifiers
PMID: 1503908
Source
Medline
License
Unknown

Abstract

Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha.

Report this publication

Statistics

Seen <100 times