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The antigenic anatomy of SARS-CoV-2 receptor binding domain

Authors
  • Dejnirattisai, Wanwisa1
  • Zhou, Daming2
  • Ginn, Helen M.2
  • Duyvesteyn, Helen M.E.2
  • Supasa, Piyada1
  • Case, James Brett3
  • Zhao, Yuguang2
  • Walter, Thomas S.2
  • Mentzer, Alexander J.1, 4
  • Liu, Chang1, 5
  • Wang, Beibei1
  • Paesen, Guido C.2
  • Slon-Campos, Jose1
  • López-Camacho, César1
  • Kafai, Natasha M.3, 6
  • Bailey, Adam L.6
  • Chen, Rita E.3, 6
  • Ying, Baoling3
  • Thompson, Craig7, 8
  • Bolton, Jai8
  • And 33 more
  • 1 Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK
  • 2 Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, OX3 7BN, UK
  • 3 Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
  • 4 Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  • 5 Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, OX3 7FZ, UK
  • 6 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
  • 7 Peter Medawar Building for Pathogen Research, Oxford, OX1 3SY, UK
  • 8 Department of Zoology, University of Oxford, Oxford, OX1 3SZ, UK
  • 9 MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK
  • 10 Sir William Dunn School of Pathology University of Oxford OX1 3RE UK
  • 11 National Infection Service, Public Health England (PHE), Porton Down, Salisbury, SP4 0JG, UK
  • 12 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK
  • 13 Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford, OX3 7LE, UK
  • 14 NIHR Oxford Biomedical Research Centre, Oxford, OX3 9DU, UK
  • 15 Worthing Hospital, Worthing, BN11 2DH, UK
  • 16 Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK
  • 17 Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham, ME4 4TB, UK
  • 18 Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, OX11 0DE, UK
  • 19 Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
  • 20 Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan
  • 21 Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
  • 22 Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110 USA
  • 23 The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110 USA
  • 24 Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, OX4 2JY, UK
Type
Published Article
Journal
Cell
Publisher
The Authors. Published by Elsevier Inc.
Publication Date
Feb 18, 2021
Identifiers
DOI: 10.1016/j.cell.2021.02.032
PMCID: PMC7891125
Source
PubMed Central
License
Unknown

Abstract

Dejnirattisai et al. present an in-depth study of the human antibody response to SARS-CoV-2 infection. By characterizing 377 human mAbs from recovered COVID-19 patients, and determining 19 protein structures, they construct a map of antibody footprints on the RBD describe in great detail its antigenic anatomy.

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