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Antigen targeting to M cells for enhancing the efficacy of mucosal vaccines.

Authors
  • Kim, Sae-Hae1
  • Jang, Yong-Suk1
  • 1 1] Department of Molecular Biology, Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju, Korea [2] Department of Bioactive Material Sciences, Research Center of Bioactive Materials, Chonbuk National University, Jeonju, Korea. , (North Korea)
Type
Published Article
Journal
Experimental & Molecular Medicine
Publisher
Springer Nature
Publication Date
Mar 14, 2014
Volume
46
Identifiers
DOI: 10.1038/emm.2013.165
PMID: 24626171
Source
Medline
License
Unknown

Abstract

Vaccination is one of the most successful applications of immunology and for a long time has depended on parenteral administration protocols. However, recent studies have pointed to the promise of mucosal vaccination because of its ease, economy and efficiency in inducing an immune response not only systemically, but also in the mucosal compartment where many pathogenic infections are initiated. However, successful mucosal vaccination requires the help of an adjuvant for the efficient delivery of vaccine material into the mucosa and the breaking of the tolerogenic environment, especially in oral mucosal immunization. Given that M cells are the main gateway to take up luminal antigens and initiate antigen-specific immune responses, understanding the role and characteristics of M cells is crucial for the development of successful mucosal vaccines. Especially, particular interest has been focused on the regulation of the tolerogenic mucosal microenvironment and the introduction of the luminal antigen into the lymphoid organ by exploiting the molecules of M cells. Here, we review the characteristics of M cells and the immune regulatory factors in mucosa that can be exploited for mucosal vaccine delivery and mucosal immune regulation.

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