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The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.

Authors
  • Imboden, J B
  • Weiss, A
  • Stobo, J D
Type
Published Article
Journal
Journal of immunology (Baltimore, Md. : 1950)
Publication Date
Feb 01, 1985
Volume
134
Issue
2
Pages
663–665
Identifiers
PMID: 3871211
Source
Medline
License
Unknown

Abstract

A monoclonal antibody to the antigen-receptor on the T cell line Jurkat induces substantial increases in [Ca++]i. Ca++ ionophores can substitute for this antibody in activation by increasing [Ca++]i to levels comparable with those seen with the antigen-receptor antibody. Stimulation with either the antigen-receptor antibody or a Ca++ ionophore leads to the appearance of the same phosphoproteins. These results suggest that the antigen-receptor initiates T cell activation by increasing [Ca++]i.

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