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Antigen-processing and presentation pathways select antigenic HIV peptides in the fight against viral evolution

Authors
  • Margulies, David H1
  • 1 Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA , Bethesda (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jun 01, 2009
Volume
10
Issue
6
Pages
566–568
Identifiers
DOI: 10.1038/ni0609-566
Source
Springer Nature
License
Yellow

Abstract

The evolution of immunodominant epitopes in HIV-1 Gag proteins correlates with quantitative measures of several antigen processing events. Thus, peptides recognized by CD8+ cytolytic T cells are selected by their ability to pass through the antigen processing pathway, as well as by their binding to HLA molecules.

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