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Antigen presentation, loss of immunological memory and AIDS.

Authors
  • Helbert, M R
  • L'age-Stehr, J
  • Mitchison, N A
Type
Published Article
Journal
Immunology Today
Publisher
Elsevier
Publication Date
Jul 01, 1993
Volume
14
Issue
7
Pages
340–344
Identifiers
PMID: 8363722
Source
Medline
License
Unknown

Abstract

A key factor causing immunodeficiency in HIV infection seems to be defective antigen presentation. Consequently, CD4+ T-cell populations, initially those expressing CD45RO, decrease in number not because of their destruction, but because they fail to expand in response to antigenic stimulation. This view implies that it would be mistaken to aim therapies only at correcting T-cell function or preventing infection of T cells.

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