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Antigen dependent and independent mechanisms that sustain serum antibody levels.

Authors
  • Traggiai, Elisabetta
  • Puzone, Roberto
  • Lanzavecchia, Antonio
Type
Published Article
Journal
Vaccine
Publisher
Elsevier
Publication Date
Jun 01, 2003
Volume
21 Suppl 2
Identifiers
PMID: 12763680
Source
Medline
License
Unknown

Abstract

In this article, we review three mechanisms that contribute to sustaining serum antibody levels: (i) long-lived plasma cells; (ii) persisting or cross-reactive antigen, and (iii) polyclonal activation of all memory B cells. We also present a quantitative analysis of the secondary immune response that reveals the relative contribution of antigen induced short- and long-lived plasma cells versus polyclonal activation of all memory B cells. Antigenic boost sustains high levels of serum antibodies only for a few months, while polyclonal activation sustains low levels of protective antibodies for a human lifetime.

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