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Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.

Authors
  • Mak, J W
  • Suresh, K
  • Lam, P L
  • Choong, M F
  • Striebel, H P
Type
Published Article
Journal
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ)
Publication Date
Mar 01, 1990
Volume
41
Issue
1
Pages
10–12
Identifiers
PMID: 2339241
Source
Medline
License
Unknown

Abstract

CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.

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