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Antidiabetic Activity of Nigella Sativa (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies

Authors
  • Maideen, Naina Mohamed Pakkir
Type
Published Article
Journal
Chonnam Medical Journal
Publisher
Chonnam National University Medical School
Publication Date
Sep 24, 2021
Volume
57
Issue
3
Pages
169–175
Identifiers
DOI: 10.4068/cmj.2021.57.3.169
PMID: 34621636
PMCID: PMC8485088
Source
PubMed Central
Keywords
Disciplines
  • Review Article
License
Unknown

Abstract

The use of herbal medicine to manage chronic conditions including diabetes has become a recent global trend. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia. The present review is aimed to analyze the antidiabetic activity of N. sativa as many type 2 diabetic patients use it as a complementary therapy along with their modern allopathic medications or as an alternative therapy. The literature was reviewed in databases like Medline/PubMed Central/PubMed, Google Scholar, Science Direct, EBSCO, Scopus, Web of science, EMBASE, Directory of open access journals (DOAJ), and reference lists to identify relevant articles supporting the use of N. sativa in diabetes management. Numerous clinical and animal studies have demonstrated the antidiabetic efficacy of black seeds ( N. sativa ) and its major bioactive constituent thymoquinone. Based on these findings patients with diabetes may use N. sativa as an adjuvant therapy, which may help to reduce the dose and incidence of adverse effects of modern antidiabetic medicines.

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