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Antidiabetic activities of entagenic acid in type 2 diabetic db/db mice and L6 myotubes via AMPK/GLUT4 pathway.

Authors
  • Xiong, Hui1
  • Zhang, Shengnan1
  • Zhao, Zhongqiu2
  • Zhao, Ping3
  • Chen, Lvyi1
  • Mei, Zhinan4
  • 1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, PR China. , (China)
  • 2 Division of Pulmonary & Critical Care Medicine, Barnes-Jewish Hospital, St. Louis, MO 63110, USA; Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.
  • 3 School of Life Sciences, South-Central University for Nationalities, Wuhan 430074, PR China. , (China)
  • 4 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, PR China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Journal of ethnopharmacology
Publication Date
Jan 30, 2018
Volume
211
Pages
366–374
Identifiers
DOI: 10.1016/j.jep.2017.10.004
PMID: 28993280
Source
Medline
Keywords
License
Unknown

Abstract

The present study demonstrated that entagenic acid can markedly maintain the glucose homeostasis, improve insulin resistance and ameliorate dyslipidemia. Its antihyperglycemic effect could be caused by promoting AMPK mediated cellular signaling and GLUT4 translocation in muscles.

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