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Anticonvulsants for neonates with seizures.

Authors
  • Booth, D
  • Evans, D J
Type
Published Article
Journal
The Cochrane database of systematic reviews
Publication Date
Jan 01, 2004
Issue
4
Identifiers
PMID: 15495087
Source
Medline
License
Unknown

Abstract

At present there is little evidence from randomised controlled trials to support the use of any of the anticonvulsants currently used in the neonatal period. In the literature, there remains a body of opinion that seizures should be treated because of the concern that seizures in themselves may be harmful, although this is only supported by relatively low grade evidence (Levene 2002; Massingale 1993). Development of safe and effective treatment strategies relies on future studies of high quality (randomised controlled trials with methodology that assures validity) and of sufficient size to have the power to detect clinically important reductions in mortality and severe neurodevelopmental disability in addition to any short term reduction in seizure burden.

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