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Anticonvulsant and hypnotic effects of amiodarone.

Authors
  • Ozbakis-Dengiz, Gunnur
  • Bakirci, Aysegul
Type
Published Article
Journal
Journal of Zhejiang University. Science. B
Publication Date
Apr 01, 2009
Volume
10
Issue
4
Pages
317–322
Identifiers
DOI: 10.1631/jzus.B0820316
PMID: 19353751
Source
Medline
License
Unknown

Abstract

Amiodarone hydrochloride is a potent anti-arrhythmic agent, known as a multiple ion-channel blocker in the heart. Although it has been detected in the rat brain, there are no data related to its central nervous system (CNS) effects. In this study, we evaluated anticonvulsant and hypnotic effects of amiodarone. Convulsions were induced by phentylenetetrazole (PTZ) (100 mg/kg) or caffeine (300 mg/kg) in mice. In both models, amiodarone prolonged both latency period and time to death, and acted as an anticonvulsant drug. It was found to be more effective in the PTZ model than in the caffeine model; none of the animals treated with 150 mg/kg dose amiodarone had died in the PTZ model. For hypnotic effect, sleeping was induced with pentobarbital (35 mg/kg) in rats. Amiodarone dose-dependently increased the sleeping time (677.7%-725.9%). In the sleeping test, all rats in 200 mg/kg amiodarone group died. In conclusion, anticonvulsant and hypnotic effects of amiodarone have shown the depressant effects on CNS. These effects may be dependent on its pharmacological properties.

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