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Anticonvulsant activity of 2-(substituted-imino)thiazolidin-4-ones.

Authors
  • Gong, G-H
  • Wang, D
  • Zhang, J-F
  • Wei, C-X
  • Quan, Z-S
Type
Published Article
Journal
Drug research
Publication Date
Jan 01, 2014
Volume
64
Issue
1
Pages
5–9
Identifiers
DOI: 10.1055/s-0033-1349095
PMID: 23955391
Source
Medline
License
Unknown

Abstract

A novel series of 2-(substituted-imino)thiazolidin-4-ones were synthesized and evaluated for anticonvulsant activity using the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (Sc-PTZ) assays and their neurotoxicity was measured by the rotarod test. The results of these tests demonstrated that 2-(4-(pentyloxy)phenylimino)thiazolidin-4-one (5d) was the most potent anticonvulsant, with ED50 value of 18.5 mg/kg and 15.3 mg/kg in the MES and Sc-PTZ tests, and protective index (PI=TD50/ED50) values of 10.6 and 12.8 respectively. 5d was much safer than a reference drug Carbamazepine.

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