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Anticancer Potential of Dietary Natural Products: A Comprehensive Review.

Authors
  • Ahmad, Rumana1
  • Khan, Mohsin A2
  • Srivastava, A N3
  • Gupta, Anamika3
  • Srivastava, Aditi3
  • Jafri, Tanvir R4
  • Siddiqui, Zainab3
  • Chaubey, Sunaina3
  • Khan, Tahmeena5
  • Srivastava, Arvind K6
  • 1 Department of Biochemistry, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj Lucknow-226003. India. , (India)
  • 2 Chancellor, Era University, Sarfarazganj, Hardoi Road, Lucknow-226003. India. , (India)
  • 3 Department of Pathology, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj Lucknow-226003. India. , (India)
  • 4 Department of Pathology, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj Lucknow-226003, UP. India. , (India)
  • 5 Department of Chemistry, Integral University, Dasauli, P.O. Bas-ha, Kursi Road, Lucknow 226026, UP. India. , (India)
  • 6 Department of Food and Nutrition, Era University, Sarfarazganj Lucknow-226003, UP. India. , (India)
Type
Published Article
Journal
Anti-cancer agents in medicinal chemistry
Publication Date
Oct 14, 2019
Identifiers
DOI: 10.2174/1871520619666191015103712
PMID: 31749433
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Nature is a rich source of natural drug-like compounds with almost zero side effects. Phytochemicals better known as "Natural Products" are found abundantly in a number of plants. Since time immemorial, spices have been widely used in Indian cuisine as flavoring and colouring agents. Most of these spices and condiments are derived from various biodiversity hotspots in India (which contributes 75% of global spice production) and form the crux of India's multidiverse and multicultural cuisine. Apart from their aroma, flavor and taste, these spices and condiments are known to possess several medicinal properties also. Most of these spices find considerable mention in Ayurveda, the indigenous system of medicine, as panaceas for several aliments. The antimicrobial, antioxidant, antiproliferative, antihypertensive and antidiabetic properties of several of these natural products are well documented in Ayurveda. These phytoconstituemts are known to act as functional immunoboosters, immunomodulators as well as anti-inflammatory agents. As anticancer agents, their mechanistic action involves cancer cell death via induction of apoptosis, necrosis and autophagy. The present review provides a comprehensive and collective update on the potential of 65 commonly used spices as well as their bioactive constituents as anticancer agents. The review also provides an in-depth update of all major in vitro, in vivo, clinical and pharmacological studies done on these spices with special emphasis on the potential of these spices and their bioactive constituents as potential functional foods for prevention, treatment and management of cancer. Copyright© Bentham Science Publishers; For any queries, please email at [email protected]

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