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Anticalcification effect of a combination of decellularization, organic solvents and amino acid detoxification on glutaraldehyde-fixed xenopericardial heart valves in a large-animal long-term circulatory model.

Authors
  • Park, Chun Soo1
  • Kim, Yong Jin2
  • Lee, Jeong Ryul3
  • Lim, Hong-Gook3, 4
  • Chang, Ji-Eun5
  • Jeong, Saeromi4
  • Kwon, Nayun4
  • 1 Division of Pediatric Cardiac Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. , (North Korea)
  • 2 Department of Thoracic and Cardiovascular Surgery, Sejong General Hospital, Sejong Heart Institute, Gyeonggi-do, Republic of Korea. , (North Korea)
  • 3 Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, Republic of Korea. , (North Korea)
  • 4 Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. , (North Korea)
  • 5 Department of Thoracic and Cardiovascular Surgery, Bundang Hospital, Seoul National University, Gyeonggi-do, Republic of Korea. , (North Korea)
Type
Published Article
Journal
Interactive Cardiovascular and Thoracic Surgery
Publisher
Oxford University Press
Publication Date
Sep 01, 2017
Volume
25
Issue
3
Pages
391–399
Identifiers
DOI: 10.1093/icvts/ivx131
PMID: 28505294
Source
Medline
Keywords
License
Unknown

Abstract

Porcine pericardial leaflets treated with our anticalcification protocol showed better function and less calcification than those treated with glutaraldehyde alone in the pulmonary position.

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