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Antibody blockade of junctional adhesion molecule-A in rabbit corneal endothelial tight junctions produces corneal swelling.

Authors
  • Mandell, Kenneth J1
  • Holley, Glenn P
  • Parkos, Charles A
  • Edelhauser, Henry F
  • 1 Emory Eye Center, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. [email protected]
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
June 2006
Volume
47
Issue
6
Pages
2408–2416
Identifiers
PMID: 16723450
Source
Medline
License
Unknown

Abstract

The results provide new evidence that JAM-A and its binding partner AF-6 are expressed in tight junctions of the corneal endothelium and that JAM-A has a major role in maintaining the corneal endothelial barrier function.

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