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Antibodies to skeletal muscle actin and their reactivity with malignant melanoma of the choroid.

Authors
  • Malaty, A
  • Rahi, A
  • Garner, A
Type
Published Article
Journal
The British journal of ophthalmology
Publication Date
Mar 01, 1980
Volume
64
Issue
3
Pages
181–185
Identifiers
PMID: 6892991
Source
Medline
License
Unknown

Abstract

Imprints of choroidal malignant melanoma cells were treated with serum containing antibodies to a purified preparation of actin derived from skeletal muscle. Evidence of a positive reaction, as shown by indirect immunofluorescence, substantiated an impression based on morphological criteria that choroidal melanoma cells contain actin protein. The significance of this protein in tumour biology is discussed, and a possible interference by antiactin antibodies in the immunodiagnosis of choroidal melanoma is highlighted.

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