Antibodies to skeletal muscle actin and their reactivity with malignant melanoma of the choroid.
- Published Article
The British journal of ophthalmology
- Publication Date
Mar 01, 1980
Imprints of choroidal malignant melanoma cells were treated with serum containing antibodies to a purified preparation of actin derived from skeletal muscle. Evidence of a positive reaction, as shown by indirect immunofluorescence, substantiated an impression based on morphological criteria that choroidal melanoma cells contain actin protein. The significance of this protein in tumour biology is discussed, and a possible interference by antiactin antibodies in the immunodiagnosis of choroidal melanoma is highlighted.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6892991