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Antibiotic resistome in a landfill leachate treatment plant and effluent-receiving river.

Authors
  • Wang, Jia-Ying1
  • An, Xin-Li2
  • Huang, Fu-Yi1
  • Su, Jian-Qiang3
  • 1 Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen, 361021, China; University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, 100049, China. , (China)
  • 2 Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen, 361021, China. , (China)
  • 3 Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen, 361021, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Chemosphere
Publication Date
Mar 01, 2020
Volume
242
Pages
125207–125207
Identifiers
DOI: 10.1016/j.chemosphere.2019.125207
PMID: 31675591
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Landfills leachate contained diverse antibiotic resistance genes (ARGs). Treated landfill leachate effluent could enter into the downstream environments, leading to the dissemination of ARGs, which might pose a health risk to public. Here, we used high-throughput qPCR to characterize the resistome and 16S rRNA-based Illumina sequencing to analyze the bacterial community in a leachate treatment plant and the river near the landfill. A total of 91 ARGs and 5 mobile genetic elements were detected. Leachate treatment process significantly changed the profiles of resistome and bacterial community structures. Similar bacterial community structure and ARG profiles were detected between effluent and downstream river, which were both dominated by multidrug and beta-lactams resistance genes and harbored higher ARG relative abundance than that in upstream river. In particular, seven ARGs were detected both in effluent and downstream river samples but not detected in upstream river, including genes encoding resistance to vancomycin (vanXD and vanSB) and carbapenem (cphA and blaGES), which implied the effects of the effluent on its receiving river. This study highlights the risk of discharge of processed landfill leachate in dissemination of antibiotic resistance determinants to the environments, and suggests an urgent need for surveillance of ARGs and development of techniques to mitigate the risk. Copyright © 2019 Elsevier Ltd. All rights reserved.

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