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Antibiotic resistance patterns of Gram-negative and Gram-positive strains isolated from inpatients with nosocomial infections in a tertiary hospital in Beijing, China from 2011 to 2014.

Authors
  • Zhu, Xiaoyan1, 2
  • Tong, Aihua1
  • Wang, Di1
  • Sun, Huijie1, 2
  • Chen, Ling3, 4
  • Dong, Mei1, 2
  • 1 a Department of Clinical Laboratory , Chinese PLA 309 Hospital , Beijing , China. , (China)
  • 2 b Graduate School, Hebei North University , Zhangjiakou , Hebei , China. , (China)
  • 3 c Graduate School , Shanxi Medical University , Taiyuan, Shanxi , China. , (China)
  • 4 d Department of Plastic Surgery and Burn Repair , Chinese PLA 309 Hospital , Beijing , China. , (China)
Type
Published Article
Journal
Journal of chemotherapy (Florence, Italy)
Publication Date
Oct 01, 2017
Volume
29
Issue
5
Pages
317–320
Identifiers
DOI: 10.1080/1120009X.2016.1157946
PMID: 27347770
Source
Medline
Keywords
License
Unknown

Abstract

This study was to evaluate the resistance of antimicrobial agents against pathogens from inpatients with nosocomial infection collected in Beijing, China, during 2011-2014. Measurement of minimum inhibitory concentrations (MICs) was carried out using the broth microdilution method with the Clinical and Laboratory Standards Institute (CLSI) guidelines as the indicator. A total of 5442 Gram-negative and 806 Gram-positive isolates were collected in this study in 2011-2014. Two carbapenem-resistant strains appeared among Escherichia coli (E. coli), while imipenem-resistant isolates increased in proportion from 0% to 8.2% among Klebsiella pneumonia (K. pneumonia) during 4 year. Acinetobacter baumannii (A. baumannii) revealed severe antibacterial resistance to most antimicrobial agents. In contrast, a decreasing trend on resistance had been observed among Pseudomonas aeruginosa (P. aeruginosa) especially after 2012, range from 1.8% for co-trimoxazole to 13.5% for piperacillin. The resistance of Staphylococcus aureus (S. aureus) also had the lowest resistant to linezolid and vancomycin (0.1%). In summary, antimicrobial-resistant nosocomial pathogens have gradually increased from 2011 to 2014, so improved surveillance of hospital-acquired infections and effective infection-control measures may be the best way to solve the present problem.

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