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Antibiotic resistance pattern and frequency of cagA and vacA genes in Helicobacter pylori strains isolated from patients in Tabriz city, Iran

Authors
  • Rasi-Bonab, Farnaz1
  • Jafari-Sales, Abolfazl2
  • Shaverdi, Mohammad Amin3, 4
  • Navidifar, Tahereh5
  • Saki, Morteza6, 6
  • Ghorbani, Atosa6
  • Adekanmbi, Abimbola Olumide7
  • Jafari, Behboud8
  • Naebi, Sara8
  • 1 Islamic Azad University, Marand, Iran , Marand (Iran)
  • 2 Islamic Azad University, Kazerun, Iran , Kazerun (Iran)
  • 3 High Institute for Research and Education in Transfusion Medicine, Tehran, Iran , Tehran (Iran)
  • 4 Khuzestan Blood Transfusion Center, Abadan, Iran , Abadan (Iran)
  • 5 Shoushtar Faculty of Medical Sciences, Shoushtar, Iran , Shoushtar (Iran)
  • 6 Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Ahvaz (Iran)
  • 7 University of Ibadan, Ibadan, Nigeria , Ibadan (Nigeria)
  • 8 Islamic Azad University, Ahar, Iran , Ahar (Iran)
Type
Published Article
Journal
BMC Research Notes
Publisher
Springer (Biomed Central Ltd.)
Publication Date
May 31, 2021
Volume
14
Issue
1
Identifiers
DOI: 10.1186/s13104-021-05633-5
Source
Springer Nature
Keywords
License
Green

Abstract

ObjectiveHelicobacter pylori is one of the most common causes of gastric infections in humans. It is estimated that approximately 50% of people around the world are infected with this bacterium. This study aimed to determine the antibiotic resistance pattern, as well as the frequency of cagA and vacA genes in H. pylori isolates obtained from patients in the clinical centers in Tabriz city, Iran.ResultsThe culture method detected 100 (45.25%) H. pylori isolates from 221 biopsy samples during 3 years. The results showed that 63% and 81% of the isolates were positive for cagA and vacA genes, respectively. The highest resistance of isolates was seen against metronidazole (79%) and amoxicillin (36%), respectively. Also, the isolates showed the least resistance to tetracycline (8%).

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