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Antibiotic prophylaxis in breast cancer surgery. A randomized controlled trial 1

Authors
  • Prudencio, Rubens Murilo de Athayde1
  • Campos, Fabíola Soares Moreira2
  • Loyola, Ana Beatriz Alkmim Teixeira3
  • Archangelo, Ivanildo Junior4
  • Novo, Neil Ferreira5
  • Ferreira, Lydia Masako6
  • Veiga, Daniela Francescato7
  • 1 Master, Professional Master’s Program in Applied Health Sciences, Universidade do Vale do Sapucaí (UNIVÁS), Pouso Alegre-MG, and Breast Cancer Unit, Hospital São Cristóvão, Sao Paulo-SP, Brazil. Conception, design, intellectual and scientific content of the study; acquisition, interpretation and analysis of data; manuscript writing; final approval.
  • 2 Master, Professional Master’s Program in Applied Health Sciences, and Hospital das Clínicas Samuel Libânio, UNIVÁS, Pouso Alegre-MG, Brazil. Conception, design, intellectual and scientific content of the study; acquisition, interpretation and analysis of data; manuscript writing; final approval.
  • 3 PhD, Associate Professor, Professional Master’s Program in Applied Health Sciences, UNIVÁS, Pouso Alegre-MG, Brazil. Conception, design, intellectual and scientific content of the study; interpretation and analysis of data; manuscript writing; critical revision; final approval.
  • 4 MD, Department of Breast Surgery, UNIVÁS, Pouso Alegre-MG, Brazil. Conception, design, intellectual and scientific content of the study; acquisition of data; final approval.
  • 5 PhD, Full Professor, Department of Biostatistics, UNIVÁS, Pouso Alegre-MG, Brazil. Interpretation of data, statistical analysis, critical revision, final approval.
  • 6 PhD, Chairwoman, Head, Postgraduate Program in Translational Surgery, Division of Plastic Surgery, Universidade Federal de São Paulo (UNIFESP), Sao Paulo-SP, Brazil. Critical revision, final approval.
  • 7 PhD, Associate Professor, Professional Master’s Program in Applied Health Sciences, UNIVÁS, Pouso Alegre-MG, and Postgraduate Program in Translational Surgery, UNIFESP, Sao Paulo-SP, Brazil. Conception, design, intellectual and scientific content of the study; interpretation and analysis of data; manuscript writing; critical revision; final approval.
Type
Published Article
Journal
Acta Cirúrgica Brasileira
Publisher
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Publication Date
Sep 30, 2020
Volume
35
Issue
9
Identifiers
DOI: 10.1590/s0102-865020200090000007
PMID: 33027362
PMCID: PMC7531055
Source
PubMed Central
Keywords
License
Green

Abstract

Purpose To assess the effect of antibiotic prophylaxis on surgical site infection (SSI) rates in women undergoing breast cancer surgery in two tertiary hospitals in Brazil. Methods This was a randomized, double-blind, placebo-controlled, parallel-group clinical trial. A total of 124 women without independent risk factors for SSI were randomly assigned to receive either cefazolin (antibiotic group, n = 62) or placebo (control group, n = 62) as preoperative prophylaxis. After surgery, all surgical wounds were examined once a week, for four weeks, according to the Centers for Disease Control and Prevention definitions and classifications for SSI. Results Baseline characteristics were homogeneous between the two groups. Only one patient in the antibiotic group developed SSI, which was classified as superficial incisional. The overall SSI rate was low, with no significant difference between groups. Conclusion Antibiotic prophylaxis had no significant effect on reducing SSI rates in women without independent risk factors for SSI undergoing breast cancer surgery.

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