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Antibiofilm properties of triclosan with EDTA or cranberry as Foley Catheter lock solutions.

Authors
  • Ayyash, M1
  • Shehabi, A A2
  • Mahmoud, N N3
  • Al-Bakri, A G1
  • 1 Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Amman, Jordan. , (Jordan)
  • 2 Department of Pathology-Microbiology, School of Medicine, The University of Jordan, Amman, Jordan. , (Jordan)
  • 3 Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan. , (Jordan)
Type
Published Article
Journal
Journal of Applied Microbiology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Dec 01, 2019
Volume
127
Issue
6
Pages
1876–1888
Identifiers
DOI: 10.1111/jam.14439
PMID: 31502331
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To investigate the efficiency of triclosan, ethylenediaminetetraacetic acid (EDTA) and cranberry alone or in combinations against Escherichia coli strains as urinary catheter lock solutions to reduce catheter-associated urinary tract infections. Viable counting was used to assess antibiofilm activities for triclosan, EDTA and cranberry alone or in combinations against E. coli strains embedded in biofilm onto all-silicon Foley catheter surface. The results revealed that combination of triclosan (10 mg ml-1 /EDTA 30 mg ml-1 ) when filling the catheter balloon was able to eradicate and prevent biofilm formation among all tested E. coli including the resistant strains, whereas triclosan (8·5 mg ml-1 )/ cranberry (103 mg ml-1 ) combination was a successful catheter lock solution by preventing all tested strains from adhering onto catheter surface when filled via the eye hole. The combinations of triclosan/EDTA and triclosan/cranberry were significantly effective in eradicating and preventing biofilm formation of the tested E. coli strains on Foley catheters. Combinations of triclosan/EDTA and triclosan/cranberry have a promising application as nonantibiotic catheter lock solution. © 2019 The Society for Applied Microbiology.

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