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The anti-biofilm and anti-virulence activities of trans-resveratrol and oxyresveratrol against uropathogenic Escherichia coli.

Authors
  • Lee, Jin-Hyung1
  • Kim, Yong-Guy1
  • Raorane, Chaitany Jayprakash1
  • Ryu, Shi Yong2
  • Shim, Jae-Jin1
  • Lee, Jintae1
  • 1 School of Chemical Engineering, Yeungnam University , Gyeongsan , Republic of Korea. , (North Korea)
  • 2 Department of Medicinal Chemistry, Korea Research Institute of Chemical Technology , Daejeon , Republic of Korea. , (North Korea)
Type
Published Article
Journal
Biofouling
Publisher
Informa UK (Taylor & Francis)
Publication Date
Aug 01, 2019
Volume
35
Issue
7
Pages
758–767
Identifiers
DOI: 10.1080/08927014.2019.1657418
PMID: 31505984
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Uropathogenic Escherichia coli (UPEC) is the primary causative agent of urinary tract infections, which are one of the most common infectious disease types in humans. UPEC infections involve bacterial cell adhesion to bladder epithelial cells, and UPEC can also form biofilms on indwelling catheters that are often tolerant to common antibiotics. In this study, the anti-biofilm activities of t-stilbene, stilbestrol, t-resveratrol, oxyresveratrol, ε-viniferin, suffruticosol A, and vitisin A were investigated against UPEC. t-Resveratrol, oxyresveratrol, and ε-viniferin, suffruticosol A, and vitisin A significantly inhibited UPEC biofilm formation at subinhibitory concentrations (10-50 μg ml-1). These findings were supported by observations that t-resveratrol and oxyresveratrol reduced fimbriae production and the swarming motility in UPEC. Furthermore, t-resveratrol and oxyresveratrol markedly diminished the hemagglutinating ability of UPEC, and enhanced UPEC killing by human whole blood. The findings show that t-resveratrol, oxyresveratrol, and resveratrol oligomers warrant further attention as antivirulence strategies against persistent UPEC infections.

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