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Antibacterial phenylspirodrimanes from the marine-derived fungus Stachybotrys sp. SCSIO 40434.

Authors
  • Mou, Pengyun1
  • Zhang, Qingbo2
  • Peng, Jing3
  • Jiang, Xiaodong3
  • Zhang, Liping2
  • Zhou, Zhongbo4
  • Zhang, Changsheng5
  • Zhu, Yiguang6
  • 1 College of Life Science, Tarim University/Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, Alar 843300, China; Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China. , (China)
  • 2 Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No.1119, Haibin Rd, Nansha District, Guangzhou 511458, China. , (China)
  • 3 Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China. , (China)
  • 4 College of Life Science, Tarim University/Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, Alar 843300, China. Electronic address: [email protected] , (China)
  • 5 Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No.1119, Haibin Rd, Nansha District, Guangzhou 511458, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China. , (China)
  • 6 Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No.1119, Haibin Rd, Nansha District, Guangzhou 511458, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Fitoterapia
Publication Date
May 15, 2021
Volume
152
Pages
104937–104937
Identifiers
DOI: 10.1016/j.fitote.2021.104937
PMID: 34000328
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Five new phenylspirodrimanes, stachybomycins A - E (1-5), together with four known compounds (6-9), were isolated from the marine-derived fungus Stachybotrys sp. SCSIO 40434. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and HRESIMS. The absolute configuration of 1 was confirmed by single crystal X-ray diffraction analysis. Compounds 5 and 7 showed moderate antibacterial activities against Micrococcus luteus, Staphylococcus aureus and methicillin resistant Staphylococcus aureus with minimal inhibition concentration (MIC) values of 8, 16 and 16 μg mL-1, respectively. Copyright © 2021 Elsevier B.V. All rights reserved.

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