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Antibacterial Activity of Rhizome of Curcuma aromatica and Partial Purification of Active Compounds.

Authors
  • 1
  • 1
  • 1 Departments of Plant Biology and Plant Biotechnology, PSGR. Krishnammal College for Women, Coimbatore-641004, India. , (India)
Type
Published Article
Journal
Indian Journal of Pharmaceutical Sciences
0250-474X
Publisher
OMICS Publishing Group
Publication Date
Volume
75
Issue
6
Pages
732–735
Identifiers
PMID: 24591751
Source
Medline
Keywords
License
Unknown

Abstract

The hexane extract of Curcuma aromatica, a plant belonging to the family Zingiberaceae was tested on 10 bacterial strains (clinical isolates and standard strains). Agar diffusion method was adopted for determining the antibacterial activity of the extract. The hexane extract was found to be active against all Gram-positive strains tested, but inactive against Gram-negative strains. The minimum inhibitory concentration and minimum bactericidal concentration were determined and found to be 539 μg/ml. The phytochemical analysis of hexane extract by gas chromatography mass spectrometry revealed the presence of 13 compounds. The crude hexane extract was partially purified by thin layer chromatography. The zone showing good antibacterial activity was analysed further by gas chromatography mass spectrometry, UV/Vis spectrophotometry and Fourier transform infrared spectroscopy, which indicated the probable presence of germacrone.

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