Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.
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Authors
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Caputo, Tiziana1
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Tran, Van Du T2
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Bararpour, Nasim3, 4
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Winkler, Carine1
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Aguileta, Gabriela1
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Trang, Khanh Bao1
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Giordano Attianese, Greta M P1
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Wilson, Anne5
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Thomas, Aurelien3, 4
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Pagni, Marco2
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Guex, Nicolas2, 6
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Desvergne, Béatrice7
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Gilardi, Federica8, 9, 10
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1
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
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(Switzerland)
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2
Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
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(Switzerland)
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3
Unit of Forensic Toxicology and Chemistry, CURML, Lausanne University Hospital, Geneva University Hospitals, Lausanne, Switzerland.
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(Switzerland)
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4
Faculty Unit of Toxicology, Faculty of Biology and Medicine, CURML, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
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(Switzerland)
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5
Department of Oncology, University of Lausanne, Epalinges, Switzerland.
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(Switzerland)
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6
Bioinformatics Competence Center, University of Lausanne, Lausanne, Switzerland.
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(Switzerland)
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7
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. [email protected].
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(Switzerland)
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8
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. [email protected].
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(Switzerland)
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9
Unit of Forensic Toxicology and Chemistry, CURML, Lausanne University Hospital, Geneva University Hospitals, Lausanne, Switzerland. [email protected].
,
(Switzerland)
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10
Faculty Unit of Toxicology, Faculty of Biology and Medicine, CURML, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland. [email protected].
,
(Switzerland)
- Type
- Published Article
- Journal
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Cellular and Molecular Life Sciences
- Publisher
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Springer-Verlag
- Publication Date
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Jan 01, 2021
- Volume
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78
- Issue
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1
- Pages
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227–247
- Identifiers
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DOI: 10.1007/s00018-020-03485-z
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PMID: 32157317
- Source
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Medline
- Keywords
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- Language
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English
- License
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Unknown
Abstract
Chronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-associated co-morbidities. However, the molecular mechanisms initiating this inflammation in WAT are poorly understood. By combining transcriptomics, ChIP-seq and modeling approaches, we studied the global early and late responses to a high-fat diet (HFD) in visceral (vWAT) and subcutaneous (scWAT) AT, the first being more prone to obesity-induced inflammation. HFD rapidly triggers proliferation of adipocyte precursors within vWAT. However, concomitant antiadipogenic signals limit vWAT hyperplastic expansion by interfering with the differentiation of proliferating adipocyte precursors. Conversely, in scWAT, residing beige adipocytes lose their oxidizing properties and allow storage of excessive fatty acids. This phase is followed by tissue hyperplastic growth and increased angiogenic signals, which further enable scWAT expansion without generating inflammation. Our data indicate that scWAT and vWAT differential ability to modulate adipocyte number and differentiation in response to obesogenic stimuli has a crucial impact on the different susceptibility to obesity-related inflammation of these adipose tissue depots.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 02/12/2021 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at
https://www.ncbi.nlm.nih.gov/pubmed/32157317
