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Anti-retinal antibodies in patients with macular telangiectasia type 2.

Authors
  • Zhu, Ling
  • Shen, Weiyong
  • Zhu, Meidong
  • Coorey, Nathan J
  • Nguyen, An P
  • Barthelmes, Daniel
  • Gillies, Mark C
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Jan 01, 2013
Volume
54
Issue
8
Pages
5675–5683
Identifiers
DOI: 10.1167/iovs.13-12050
PMID: 23882694
Source
Medline
Keywords
License
Unknown

Abstract

We found that most patients with MacTel-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B. The localization of retinal proteins bound by AGL, RBP3, and CK-B autoantibodies is consistent with their putative physiological functions. These findings provide potentially novel mechanisms for the etiology and pathogenesis of MacTel-2.

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