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Anti-nociceptive, analgesic and pathohistological effects of intrathecal dexmedetomidine and bupivacaine in rats.

Authors
  • Erdivanli, Başar
  • Altun, Murat
  • Sezen, Ozlem K
  • Colakoğlu, Serhan A
Type
Published Article
Journal
Brazilian journal of anesthesiology (Elsevier)
Publication Date
Jan 01, 2013
Volume
63
Issue
2
Pages
183–187
Identifiers
DOI: 10.1016/S0034-7094(13)70212-5
PMID: 23601258
Source
Medline
License
Unknown

Abstract

There were no apparent pathohistological changes at least 24 hours after the intrathecal administration of a single dose of dexmedetomidine 3 μg and 10 μg. Dexmedetomidine added to bupivacaine for spinal block improves analgesia and prolongs block duration.

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