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Anti-microbial activities of sulfonamides using disc diffusion method.

Authors
  • Ahmad, Saba
  • Farrukh, Muhammad Akhyar
Type
Published Article
Journal
Pakistan journal of pharmaceutical sciences
Publication Date
Oct 01, 2012
Volume
25
Issue
4
Pages
839–844
Identifiers
PMID: 23010002
Source
Medline
License
Unknown

Abstract

Sulfonamides, being the member of the oldest anti-microbial group of compounds possess wide anti-microbial activities and are effective against pathogenic strains of gram-positive and gram-negative bacteria. They are widely used in the treatment of various infectious diseases e.g. malaria, urinary tract infections, respiratory tract infections etc. Based on their effectiveness against most of the bacteria, two novel sulfonamides (N-(2-methoxy phenyl)-4-methylbenzenesulfonamide and N-ethyl-4-methyl-N-(3-methyl phenyl)benzenesulfonamide) were synthesized. The compounds were characterized by FT-IR and elemental analyzer. Their anti-microbial activity was assessed and observed against gram-positive and gram-negative bacteria using disc diffusion method. They showed good anti-microbial activities.

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