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Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer.

Authors
  • Nagaraj, Srinivas
  • Youn, Je-In
  • Weber, Hannah
  • Iclozan, Cristina
  • Lu, Lily
  • Cotter, Matthew J
  • Meyer, Colin
  • Becerra, Carlos R
  • Fishman, Mayer
  • Antonia, Scott
  • Sporn, Michael B
  • Liby, Karen T
  • Rawal, Bhupendra
  • Lee, Ji-Hyun
  • Gabrilovich, Dmitry I
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Mar 15, 2010
Volume
16
Issue
6
Pages
1812–1823
Identifiers
DOI: 10.1158/1078-0432.CCR-09-3272
PMID: 20215551
Source
Medline
License
Unknown

Abstract

CDDO-Me abrogated the immune suppressive effect of MDSCs and improved immune responses in tumor-bearing mice and cancer patients. It may represent an attractive therapeutic option by enhancing the effect of cancer immunotherapy.

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