Affordable Access

Anti-inflammatory and platelet anti-aggregant activity of phospholipase-A2 inhibitors.

Authors
  • Vallee, E
  • Gougat, J
  • Navarro, J
  • Delahayes, J F
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Sep 01, 1979
Volume
31
Issue
9
Pages
588–592
Identifiers
PMID: 41058
Source
Medline
License
Unknown

Abstract

Mepacrine, papaverine, p-bromophenacyl bromide and 2,3-dibromo(4'-cyclohexyl-3'-chloro)-phenyl-4-oxo-butyric acid (CB 874) inhibit the hydrolysis of phospholipids induced by thrombin in dog platelets. They also exhibit anti-inflammatory and anti-aggregant properties. These biological activities may be explained by a direct or indirect inhibitory action on phospholipase A2. Phospholipase A2 inhibitors may block not only the release of arachidonic acid and its subsequent conversion into prostaglandins but also the formation of lysophospholipids involved in inflammation and/or platelet aggregation.

Report this publication

Statistics

Seen <100 times