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Anti-inflammatory and gastroprotective activities of the aqueous extract of Micromeria fruticosa (L.) Druce ssp Serpyllifolia in mice.

Authors
  • Abu-Gharbieh, Eman
  • Shehab, Naglaa Gamil
  • Khan, Saeed Ahmed
Type
Published Article
Journal
Pakistan journal of pharmaceutical sciences
Publication Date
Jul 01, 2013
Volume
26
Issue
4
Pages
799–803
Identifiers
PMID: 23811461
Source
Medline
License
Unknown

Abstract

Micromeria fruticosa is used widely in many Mediterranean regions for various inflammatory conditions. The aim of this work was to assess the anti-inflammatory and gastroprotective activities of the aqueous extract of Micromeria fruticosa. The aqueous extract of Micromeria fruticosa was tested orally in mice at doses of 50, 100 and 200 mg/kg in carrageenan-induced paw edema, vascular permeability, myeloperoxidase activity (MPO) and indomethacin-induced gastric ulceration. In the paw edema model, the extract at dose of 200 mg/ kg, exhibited a significant anti-inflammatory effect, while the extract at 100 and 200 mg/kg reduced significantly the vascular permeability and MPO activity in a dose dependant manner. Oral pretreatment of the aqueous extract reduced significantly the development of gastric lesions induced by indomethacin at dose of 200 mg/kg only. Results suggest that the aqueous extract of Micromeria fruticosa has both anti-inflammatory as well as, gastroprotective activities. Thus it could be used as an alternative or supplementary herbal remedy for the treatment of inflammatory diseases especially when combined with strong anti-inflammatory medications that have ulcerogenic side effects such as NSAIDs.

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