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Anti-Inflammatory and Anticancer Drugs from Nature

Authors
Type
Published Article
Journal
Cancer Treatment and Research
Publisher
Springer Science + Business Media
Publication Date
Oct 10, 2013
Pages
143–143
Identifiers
DOI: 10.1007/978-3-642-38007-5_8
Source
LBMCC
Keywords
License
Green

Abstract

Over the centuries, plant extracts have been used to treat various diseases. Until now, natural products have played an important role in anticancer therapy as there are more than 500 compounds from terrestrial and marine plants or microorganisms, which have antioxidant, antiproliferative, or antiangiogenic properties and are therefore able to reduce tumor growth. The recent discovery of new natural products has been accelerated by novel technologies (high throughput screening of natural products in plants, animals, marine organisms, and microorganisms). Vincristine, irinotecan, etoposide, and paclitaxel are examples of compounds derived from plants that are used in cancer treatment. Similarly, actinomycin D, mitomycin C, bleomycin, doxorubicin, and L-asparaginase are drugs derived from microorganisms. In this review, we describe the molecular mechanisms of natural compounds with anti-inflamma-tory and anticancer activities., Ó Springer-Verlag Berlin Heidelberg 2014 123 Abbreviations VEGF Vascular endothelial growth factor ROS Reactive oxygen species NF-jB Transcription factor nuclear factor jB N-pyrazinecarbonyl-L-phenyl-alanine-L-leucine boronic acid Bortezomib BAFF B-cell activating factor NIK NF-jB-inducing kinase STAT Signal transducer and activator of transcription COX-2 Cyclooxygenase-2 CDK Cyclin-dependent kinase EEF2 Eukaryotic elongation factor 2 PKC Protein kinase C PI 3 K Phosphoinositide 3-kinase MAPK Mitogen-activated protein kinase MLCK Myosin light-chain kinase ATM Ataxia telangiectasia mutated PAL Phenylalanine ammonia-lyase EGCG Epigallocatechin gallate IKK Inhibits IjB kinase DHA Docosahexaenoic acid EPA Eicosapentaenoic acid ETA 11,14,17-eicosatrienoic acid

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