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Anti-inflammatory activity of hydroxyachillin, a sesquiterpene lactone from Tanacetum microphyllum.

Authors
  • Abad, M J1
  • Bermejo, P
  • Valverde, S
  • Villar, A
  • 1 Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain.
Type
Published Article
Journal
Planta medica
Publication Date
June 1994
Volume
60
Issue
3
Pages
228–231
Identifiers
PMID: 8073088
Source
Medline
License
Unknown

Abstract

The aerial parts of Tanacetum microphyllum D.C. (Compositae), used in folk medicine as an anti-inflammatory and anti-ulcer agent, were studied, the active principle hydroxyachillin (1) was isolated, and its pharmacological properties were analyzed. Hydroxyachillin showed marked anti-inflammatory activity in carrageenan-induced paw edema in mice. In the experimental models in vitro, hydroxyachillin has been reported to be a dual inhibitor of cyclooxygenase and soybean lipoxygenase. In this study, inhibition of prostaglandin synthetase (bovine seminal vesicular microsomes) by hydroxyachillin required concentrations more than twice those which inhibited soybean lipoxygenase (ED50 values = 10(-4) M and 2.6 x 10(-5) M, respectively). Therefore, an inhibition of leukotriene synthesis might be involved in the anti-inflammatory activity of hydroxyachillin in vivo.

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