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[Anti-inflammatory action of PPARs].

Authors
  • Fujii, Hiroshi
Type
Published Article
Journal
Nihon rinsho. Japanese journal of clinical medicine
Publication Date
Apr 01, 2005
Volume
63
Issue
4
Pages
609–615
Identifiers
PMID: 15828228
Source
Medline
License
Unknown

Abstract

The PPARs transduce a wide variety of signals, including environmental and nutritional events, into a defined and ordered set of cellular responses at the transcriptional level. It has now been shown that all three PPAR isoforms (alpha, beta/delta and gamma) can participate in the regulation of inflammation responses. The ability of the PPARs to regulate inflammatory responses is a result of their transactivation and transrepression capacities. Most of the anti-inflammatory properties of the PPARs arise through their ability to antagonize nuclear factor-kappaB (NF-kappaB) and AP1 signaling pathways. By inhibiting these inflammatory transcription factors, the PPARs repress the expression of several genes that are involved in the inflammatory responses. In this review, I focus on emerging knowledge about PPARs roles in inflammatory responses.

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