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Anti-H-2 antibodies induced by syngeneic immunization.

Authors
  • Iványi, P
  • van Mourik, P
  • Breuning, M
  • Melief, C J
Type
Published Article
Journal
Immunogenetics
Publication Date
Jan 01, 1980
Volume
10
Issue
4
Pages
319–332
Identifiers
PMID: 22457924
Source
Medline
License
Unknown

Abstract

Abstract. Alloreactive cytotoxic antibodies were induced in BALB/c mice by syngeneic immunization with normal lymphoid cells. Sixteen out of 41 mice produced antibodies with distinct anti-H-2 specificity. Anti-Kk antibodies were present in all positive sera, but the individual sera produced different reactivity patterns when tested on a panel of H-2 haplotypes. Absorption and immunoprecipitation experiments confirmed the H-2 specificity of the syngeneic sera. We hypothesize that virus-modified H-2d structures have triggered alloreactive B-cell clones to produce anti-H-2 antibodies.

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