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Anti-GM1 and anti-sulfatide antibodies in patients with systemic lupus erythematosus, Sjögren's syndrome, mixed cryoglobulinemia and idiopathic systemic vasculitis.

Authors
  • Alpa, M
  • Ferrero, B
  • Cavallo, R
  • Perna, A
  • Naretto, C
  • Gennaro, M
  • Di Simone, D
  • Bellizia, L
  • Mansouri, M
  • Rossi, D
  • Modena, V
  • Giachino, O
  • Sena, L M
  • Roccatello, D
Type
Published Article
Journal
Clinical and experimental rheumatology
Publication Date
Jan 01, 2007
Volume
25
Issue
4
Pages
556–562
Identifiers
PMID: 17888211
Source
Medline
License
Unknown

Abstract

Anti-GM1 and anti-sulfatide antibodies are frequently found in patients with small vessel ANCA-associated vasculitis and other multi-organ immune-mediated diseases. Upon detection of these antibodies, accurate neurologic examination should be carried out due to the significant association that can be found between these serologic abnormalities and the involvement of the peripheral nervous system as also detected by electrophysiologic studies. This study supports the unexpected possibility that anti-neuronal reactivity may be a direct trigger of neurologic injury in these systemic disorders.

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