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Anti dermatophytic therapy--prospects for the discovery of new drugs from natural products.

Authors
  • Soares, Luciana Arantes1
  • de Cássia Orlandi Sardi, Janaína1
  • Gullo, Fernanda Patrícia1
  • de Souza Pitangui, Nayla1
  • Scorzoni, Liliana1
  • Leite, Fernanda Sangalli1
  • Giannini, Maria José Soares Mendes1
  • Almeida, Ana Marisa Fusco1
  • 1 Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio Mesquita Filho", Araraquara, SP, Brazil. , (Brazil)
Type
Published Article
Journal
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Publication Date
Dec 01, 2013
Volume
44
Issue
4
Pages
1035–1041
Identifiers
DOI: 10.1590/S1517-83822014005000011
PMID: 24688490
Source
Medline
Keywords
License
Unknown

Abstract

Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments.

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