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Anti-aging effect of Blakeslea trispora powder on adult mice

Authors
  • Hu, Weilian1
  • Dai, Dehui1
  • Li, Wei2
  • 1 School of Biology and Chemical Engineering, Zhejiang University of Science and Technology, 318# Liu He Lu, Hangzhou, Zhejiang, 310023, China , Hangzhou (China)
  • 2 Zhejiang Academy of Medical Sciences, Zhejiang Center of Laboratory Animals, Hangzhou, 310013, China , Hangzhou (China)
Type
Published Article
Journal
Biotechnology Letters
Publisher
Springer-Verlag
Publication Date
May 01, 2013
Volume
35
Issue
8
Pages
1309–1315
Identifiers
DOI: 10.1007/s10529-013-1206-6
Source
Springer Nature
Keywords
License
Yellow

Abstract

Blakeslea trispora powder that contains 1.9 % lycopene was tested for its anti-aging effect on adult mice. 48 adult mice were administered with the powder at 0, 267, 534, 1,068 mg lycopene kg−1 body daily for 30 days. The body weight, hematology, clinical chemical and antioxidant activities in major organs of adult mice were measured. The powder had no effect on the body weight, hematology, clinical chemical parameters of adult mice but improved the antioxidant activities in major organs of adult mice. Increased activities of superoxide dismutase, catalase and glutathione peroxidase and a decreased amount of malondialdehyde in liver, brain, kidney and skin of adult mice when a high-dose of the B. trispora powder was administered, suggests that it has the ability to enhance the antioxidation system and improve the anti-aging abilities of adult mice.

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