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Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

Authors
  • Cerella, Claudia
  • Gaigneaux, Anthoula
  • Dicato, Mario
  • Diederich, Marc1, 2, 3, 4
  • 1 Laboratoire de Biologie Moléculaire et Cellulaire de Cancer
  • 2 Department of Pharmacy
  • 3 College of Pharmacy
  • 4 Seoul National University
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jan 01, 2014
Identifiers
DOI: 10.1016/j.canlet.2014.02.008
Source
Elsevier
Keywords
License
Unknown

Abstract

Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter of a metabolic network controlling upstream and downstream modulation of these same genes.Natural compounds represent a source of anti-cancer molecules with chemopreventive and therapeutic properties. This review describes selected pathways and genes orchestrating the metabolic reprogramming and discusses the potential of natural compounds to target oncogenic metabolic aberrations.

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