Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming
- Authors
- Type
- Published Article
- Journal
- Cancer Letters
- Publisher
- Elsevier
- Publication Date
- Jan 01, 2014
- Identifiers
- DOI: 10.1016/j.canlet.2014.02.008
- Source
- Elsevier
- Keywords
- License
- Unknown
Abstract
Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter of a metabolic network controlling upstream and downstream modulation of these same genes.Natural compounds represent a source of anti-cancer molecules with chemopreventive and therapeutic properties. This review describes selected pathways and genes orchestrating the metabolic reprogramming and discusses the potential of natural compounds to target oncogenic metabolic aberrations.