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Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.canlet.2014.02.008
Source
LBMCC
Keywords
License
Green

Abstract

Cells reprogram their metabolism very early during carcinogenesis; this event is critical for the establishment of other cancer hallmarks. Many oncogenes and tumor suppressor genes control metabolism by interplaying with the existing nutrient-sensing intracellular pathways. Mammalian target of rapamycin, mTOR, is emerging as a collector and sorter of a metabolic network controlling upstream and downstream modulation of these same genes. Natural compounds represent a source of anti-cancer molecules with chemopreventive and therapeutic properties. This review describes selected pathways and genes orchestrating the metabolic reprogramming and discusses the potential of natural compounds to target oncogenic metabolic aberrations.

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