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Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade

Authors
  • Bonavita, Eduardo1
  • Bromley, Christian P.1
  • Jonsson, Gustav2
  • Pelly, Victoria S.1
  • Sahoo, Sudhakar1
  • Walwyn-Brown, Katherine3
  • Mensurado, Sofia4
  • Moeini, Agrin1
  • Flanagan, Eimear1
  • Bell, Charlotte R.1
  • Chiang, Shih-Chieh1
  • Chikkanna-Gowda, C.P.1
  • Rogers, Neil5
  • Silva-Santos, Bruno4
  • Jaillon, Sebastien6
  • Mantovani, Alberto6
  • Reis e Sousa, Caetano5
  • Guerra, Nadia2
  • Davis, Daniel M.3
  • Zelenay, Santiago1
  • 1 Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, UK
  • 2 Department of Life Sciences, Imperial College London, London, UK
  • 3 Manchester Collaborative Centre for Inflammation Research, The Lydia Becker Institute of Immunology and Inflammation, The University of Manchester, Manchester, UK
  • 4 Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
  • 5 The Francis Crick Institute, London, UK
  • 6 Humanitas University, Department of Biomedical Sciences, Humanitas Clinical and Research Center, IRCCS, Milan, Italy
Type
Published Article
Journal
Immunity
Publication Date
Dec 15, 2020
Volume
53
Issue
6
Pages
1215–1229
Identifiers
DOI: 10.1016/j.immuni.2020.10.020
PMID: 33220234
PMCID: PMC7772804
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Inflammation can fuel or suppress cancer. Bonavita et al. identify NK cells as primary orchestrators of T cell inflammation in murine models and devise an inflammatory signature that predicts patient survival and response to immunotherapy in multiple malignancies.

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